Research

Tissue Culture Models

By using an air liquid interface (ALI) technique, we are able to differentiate human bronchial and nasal epithelial cells to form a polarized epithelium which is an excellent model for evaluating the effect of drugs, and interventions on airway inflammation and cellular development.

Our models include IL-8 (neutrophil dominated inflammation), IL-13 (Goblet cell hyperplasia), IL-17 (Th17) and Poly-IC (Viral inflammation), and TGF-β (Airway Remodeling). Also, we developed a co-culture model of Cardiac Myofibroblasts and Human Bronchial Epithelial Cells (NHBE) in order to evaluate airway remodeling.

 

Tissue Picture